Blar i forfatter "Raknes, Guttorm"
-
Changes in the consumption of antiepileptics and psychotropic medicines after starting low dose naltrexone: A nation-wide register-based controlled before-after study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-21)In this controlled before-after study based on data from the Norwegian Prescription Database, we examine whether starting off-label use of Low Dose Naltrexone (LDN) is followed by changes in the consumption of psychotropic medicines including antiepileptics. Patients that collected LDN for the first time in 2013 (N = 11247) were included and stratified into three groups based on LDN exposure. We ... -
The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
Raknes, Guttorm; Simonsen, Pia; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ... -
Low dose naltrexone in multiple sclerosis: Effects on medication use. A quasi-experimental study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-03)Low dose naltrexone (LDN) has become a popular off-label therapy for multiple sclerosis (MS). A few small, randomized studies indicate that LDN may have beneficial effects in MS and other autoimmune diseases. If proven efficacious, it would be a cheap and safe alternative to the expensive treatments currently recommended for MS. We investigated whether a sudden increase in LDN use in Norway in 2013 ... -
Low dose naltrexone: Effects on medication in rheumatoid and seropositive arthritis. A nationwide register-based controlled quasi-experimental before-after study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-14)In recent years, low dose naltrexone (LDN) has been used as an off-label therapy for several chronic diseases. Results from small laboratory and clinical studies indicate some beneficial effects of LDN in autoimmune diseases, but clinical research on LDN in rheumatic disease is limited. Using a pharmacoepidemiological approach, we wanted to test the hypothesis that starting LDN leads to reduced ... -
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): A quasi-experimental before-after study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-01)<i>Background</i> - Low dose naltrexone (LDN) is reported to have beneficial effects in several autoimmune diseases. The purpose of this study was to examine whether starting LDN was followed by changes in the dispensing of thyroid hormones to patients with hypothyroidism.<p> <p><i>Methods</i> - We performed a quasi-experimental before-after study based on the Norwegian Prescription Database. ... -
A sudden and unprecedented increase in low dose naltrexone (LDN) prescribing in Norway. Patient and prescriber characteristics, and dispense patterns. A drug utilization cohort study
Raknes, Guttorm; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-26)Purpose: Following a TV documentary in 2013, there was a tremendous increase in low dose naltrexone (LDN) use in a wide range of unapproved indications in Norway. We aim to describe the extent of this sudden and unprecedented increase in LDN prescribing, to characterize patients and LDN prescribers, and to estimate LDN dose sizes.<br> Methods: LDN prescriptions recorded in the Norwegian Prescription ...